For information on a research trial, contact the Research Office at
469.814.4720 or THHBPResearchDepartment@bswhealth.org.
Principal Investigator: Robert L. Smith, II, MD / Molly Szerlip, MD
Evaluate the safety and function of the CardiAQ Transcatheter Mitral Valve Implant System with the Transseptal and Transapical Delivery Systems.
Principal Investigator: Robert L. Smith, II, MD
A randomized, control trial of CardioBand to optimized medical management for treatment of functional mitral regurgitation in patients who are poor surgical candidates.
Principal Investigator: Paul Grayburn, MD
Cardiovascular Outcomes Assessment of the MitraClip® Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation - Compare the performance of the investigational MitraClip® system plus optimal drug therapy with optimal drug therapy alone.
Establish the safety and effectiveness of the Edwards SAPIEN 3™ (Edwards Lifesciences™, Irvine, California) Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis.
Principal Investigators: David L. Brown, MD / Michael Mack, MD
Establish the safety and effectiveness of the Edwards SAPIEN 3™ (Edwards Lifesciences™, Irvine, California)Transcatheter Heart Valve (THV)in patients with severe, calcific, symptomatic aortic stenosis who are at low operative risk for standard aortic valve replacement (AVR).
PARTNER 3 Trial - Mitral Valve in Valve
Principal Investigator: David L. Brown, MD
To assess the safety and effectiveness of the SAPIEN 3™ (Edwards Lifesciences, Irvine, California) transcatheter heart valve in patients with a failing mitral bioprosthetic valve.
A nonrandomized safety and efficacy study for patients with severe mitral valve regurgiation, which hopes to offer this unique PASCAL edge-to-edge repair to a much wider range of mitral regurgitation patients.
PVL in TAVR
Principal Investigator: Deepika Gopal, MD
A Novel Imaging Approach to Assess Paravalvular Leak for Transcatheter Valve Replacement - Assess the agreement between cMRI PVL grading (based on regurgitant fraction) and TTE PVL grading (based on pressure, half-time, and the ratio of the jet arch to the circumference of the annulus).
Establish the safety and feasibility of the Edwards SAPIEN 3™ valve in subjects with mitral annular calcification (MAC) associated with mitral stenosis (MS) and/or mitral regurgitation who are at high-risk for mitral valve surgery or deemed inoperable due to the extent of calcification.
Physicians are members of the medical staff at one of Baylor Health Care System's subsidiary, community or affiliated medical centers and are neither employees nor agents of those medical centers, The Heart Hospital Baylor Plano or Baylor Health Care System.