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​​​​​For information on a research trial, contact the Research Office at 469.814.4720 or THHBPResearchDepartment@bswhealth.org.​


VALVE

4D CT TAVR

Principal Investigator: Ambarish Gopal, MD

4D CT to Evaluate Valve Thrombosis after Transcatheter Aortic Valve Replacement - Identify the incidence of valve thrombosis in patients referred for 4D CT evaluation due to clinical and/or echocardiographic criteria at The Heart Hospital Baylor Plano.

CardiAQ-Fortis

Principal Investigator: Robert L. Smith, II, MD / Molly Szerlip, MD

Evaluate the safety and function of the CardiAQ Transcatheter Mitral Valve Implant System with the Transseptal and Transapical Delivery Systems.

CardioBand

Principal Investigator: Robert L. Smith, II, MD

A randomized, control trial of CardioBand to optimized medical management for treatment of functional mitral regurgitation in patients who are poor surgical candidates.

COAPT

Principal Investigator: Paul Grayburn, MD

Cardiovascular Outcomes Assessment of the MitraClip® Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation - Compare the performance of the investigational MitraClip® system plus optimal drug therapy with optimal drug therapy alone.

Early TAVR

Principal Investigator: Elizabeth Holper, MD

Establish the safety and effectiveness of the Edwards SAPIEN 3™ (Edwards Lifesciences™, Irvine, California) Transcatheter Heart Valve (THV) compared with clinical surveillance (CS) in asymptomatic patients with severe, calcific aortic stenosis.

​Partner 3

Principal Investigators: David L. Brown, MD / Michael Mack, MD

Establish the safety and effectiveness of the Edwards SAPIEN 3™ (Edwards Lifesciences™, Irvine, California)Transcatheter Heart Valve (THV)in patients with severe, calcific, symptomatic aortic stenosis who are at low operative risk for standard aortic valve replacement (AVR).

PASCAL

Principal Investigator: Robert L. Smith, II, MD

A nonrandomized safety and efficacy study for patients with severe mitral valve regurgiation, which hopes to offer this unique PASCAL edge-to-edge repair to a much wider range of mitral regurgitation patients.

PVL in TAVR

Principal Investigator: Deepika Gopal, MD

A Novel Imaging Approach to Assess Paravalvular Leak for Transcatheter Valve Replacement - Assess the agreement between cMRI PVL grading (based on regurgitant fraction) and TTE PVL grading (based on pressure, half-time, and the ratio of the jet arch to the circumference of the annulus).

SITRAL

Principal Investigator: Robert L. Smith, II, MD

Establish the safety and feasibility of the Edwards SAPIEN 3™ valve in subjects with mitral annular calcification (MAC) associated with mitral stenosis (MS) and/or mitral regurgitation who are at high-risk for mitral valve surgery or deemed inoperable due to the extent of calcification.​​​​

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​​​​​​​​BAYLOR SCOTT & WHITE RESEARCH ​INSTITUTE​